Antiretroviral therapy initiation is not associated with risky sexual behavior among heterosexual human immunodeficiency virus-infected persons in serodiscordant partnerships

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From: Sexually Transmitted Diseases(Vol. 44, Issue 1)
Publisher: American Venereal Disease Association
Document Type: Author abstract; Report
Length: 271 words

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Abstract :

Background: Few prospective studies have assessed whether antiretroviral therapy (ART) use is associated with changes in sexual risk behavior of human immunodeficiency virus (HIV)-infected persons in known HIV-serodiscordant partnerships. Methods: We conducted a longitudinal analysis of HIV-infected persons with known uninfected partners enrolled in the Partners Pre-Exposure Prophylaxis Study in Kenya and Uganda. Antiretroviral therapy use and self-reported sexual behavior were ascertained every 3 months. We assessed the effect of ART on sexual risk behaviors using zero-inflated negative binomial regression. Primary outcomes were condomless vaginal sex acts, pregnancy incidence and new sexually transmitted infection diagnoses. Results: We followed 1817 HIV-infected persons (58% women) for 864 person-years before ART initiation and 771 person-years after ART. Median CD4 and plasma viral load at ART initiation were 277 cells/pL and 4.18 logio copies/mL. Antiretroviral therapy use was associated with a significant decrease in condomless vaginal sex acts with HIV-uninfected partners (0.65 vs 0.39 per month; rate ratio, 0.64; 95% confidence interval [Cl], 0.55-0.75; P Conclusions: Substantial risk compensation did not occur after ART initiation among East African HIV-infected persons with known HTV-uninfected partners. These data inform modelling studies of ART for HIV prevention by suggesting that risky sexual behavior did not appear to offset decreased HIV infectiousness in this key population. DOI: 10.1097/OLQ.0000000000000534

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Gale Document Number: GALE|A477085006