Effects of Danhong Injection (丹红注å°æ¶²) on Peri-Procedural Myocardial Injury and Microcirculatory Resistance in Patients with Unstable Angina Undergoing Elective Percutaneous Coronary Intervention: A Pilot Randomized Study.

Citation metadata

From: Chinese Journal of Integrative Medicine(Vol. 27, Issue 11)
Publisher: Springer
Document Type: Clinical report
Length: 431 words

Document controls

Main content

Abstract :

Keywords: peri-procedural myocardial injury; percutaneous coronary intervention; microcirculatory resistance; microvascular dysfunction Abstract Objective To evaluate the effect of Danhong Injection (丹红注å°æ¶², DH) on the index of microcirculatory resistance (IMR) and myocardial injury in patients with unstable angina undergoing elective percutaneous coronary intervention (PCI). Methods Seventy-eight patients with unstable angina were randomly divided into DH group (39 cases) and the control group (39 cases) during elective PCI. Randomization was performed using a random-number table. The DH group received DH at a dosage of 40 mL (mixed with 250 mL saline, covered by a light-proof bag, intravenous drip) during PCI and daily for 7 consecutive days, while the control group only received the same dosage of saline. Both groups received standardized treatment. The IMR and fractional flow reserve (FFR) were measured at maximal hyperemia before and after PCI. Myocardial markers, including myoglobin, creatine kinase (CK), creatine kinase MB (CK-MB), and coronary troponin T (cTnT) values were measured at baseline and 24 h after PCI. Results Among the 78 patients enrolled, the baseline and procedural characteristics were similar between the two groups. There was no significant difference in pre-PCI myocardial markers and coronary physiological indexes between the two groups. However, post-PCI CK and CK-MB levels in the DH group were significantly lower than those in the control group (111.97 ± 80.97 vs. 165.47 ± 102.99, P=0.013 13.08 ± 6.90 vs. 19.75 ± 15.49, P=0.016). Post-PCI myoglobin and cTNT-positive tend to be lower in the DH group than in the control group but did not reach statistical significance (88.07 ± 52.36 vs. 108.13 ± 90.94, P=0.52 2.56% vs.7.69%, P=0.065). Compared with the control group, the post-IMR levels of the DH group tended to decrease, but there was no statistical difference (20.73 ± 13.15 vs. 26.37 ± 12.31, P=0.05). There were no statistical differences in post-FFR in both groups. The peri-procedural myocardial injury of the DH group was significantly lower than that of the control group (2.56% vs. 15.38%, P=0.025). During the 30-d follow-up period, no major adverse cardiovascular events occurred in either group. Conclusion This study demonstrated benefit of DH in reducing myocardial injury and potential preserving microvascular function in patients with unstable angina undergoing elective PCI. Author Affiliation: (1) Department of Cardiology, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, 100010, Beijing, China (2) Department of Cardiology, Fuwai Hospital, 100037, Beijing, China (c) lhx_@263.net Article History: Registration Date: 07/13/2021 Accepted Date: 09/25/2020 Online Date: 07/14/2021 Byline: Wen-long Xing (1), Yong-jian Wu (2), Hong-xu Liu (corresponding author) (1, c), Qing-rong Liu (2), Qi Zhou (1), Ai-yong Li (1), Zhu-hua Zhang (1), Xuan Li (1)

Source Citation

Source Citation   

Gale Document Number: GALE|A681341751