The Gut Microbiome Is Associated with Circulating Dietary Biomarkers of Fruit and Vegetable Intake in a Multiethnic Cohort.

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Publisher: Elsevier Science Publishers
Document Type: Report
Length: 643 words

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Keywords Microbiome; Food; Nutrient; Biomarkers; Ethnicity Abstract Background Results from observational studies suggest high diet quality favorably influences the human gut microbiome. Fruit and vegetable consumption is often a key contributor to high diet quality. Objective To evaluate measures of gut bacterial diversity and abundance in relation to serum biomarkers of fruit and vegetable intake. Design Secondary analysis of cross-sectional data. Participants and setting Men and women from Los Angeles, CA, and Hawai'i who participated in the Multiethnic Cohort--Adiposity Phenotype Study from 2013 to 2016 (N = 1,709). Main outcome measures Gut microbiome diversity and composition in relation to dietary biomarkers. Statistical analysis Carotenoid (beta carotene, alpha carotene, cryptoxanthins, lutein, lycopene, and zeaxanthin), tocopherol ([alpha], [beta] + [gamma], and [delta]), and retinol concentrations were assessed in serum. The [alpha] and [beta] diversity and composition of the gut microbiome were classified based on 16S rRNA gene sequencing of bacterial DNA from self-collected fecal samples. Global differences in microbial community profiles in relation dietary biomarkers were evaluated using multivariable permutational analysis of variance. Associations of [alpha] diversity (Shannon index), [beta] diversity (weighted and unweighted UniFrac) with center log-ratio--transformed phyla and genera abundances were evaluated using linear regression, adjusted for covariates. Results Increasing total carotenoid, beta carotene, alpha carotene, cryptoxanthin, and lycopene concentrations were associated with higher gut bacterial diversity (Shannon Index) (P Conclusions Objective biomarkers of fruit and vegetable intake, particularly carotenoids, were favorably associated with gut bacterial composition and diversity in this multiethnic population. These observations provide supportive evidence that fruit and vegetable intake is related to gut bacterial composition; more work is needed to elucidate how this influences host health. Author Affiliation: (1) Department of Global and Community Health, George Mason University, Fairfax, VA (2) Fred Hutchinson Cancer Research Center, Seattle, WA (3) University of Hawaii Cancer Center, Honolulu (4) Keck School of Medicine, University of Southern California, Los Angeles (5) Population Sciences in the Pacific Program, University of Hawaii Cancer Center, Honolulu (6) Cancer Biology Program, University of Hawaii Cancer Center, Honolulu * Address correspondence to: Johanna W. Lampe, PhD, RD, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave, N, Seattle, WA 98109. Article History: Received 12 November 2020; Accepted 20 May 2021 (footnote) STATEMENT OF POTENTIAL CONFLICT OF INTEREST No potential conflict of interest was reported by the authors. (footnote) FUNDING/SUPPORT This work was supported by US National Cancer Institute grants P01CA168530, U01CA164973, P30 CA071789, P30 CA015704, and UL1TR000130. (footnote) AUTHOR CONTRIBUTIONS M. A. J. Hullar, G. Maskarinec, K. R. Monroe, J. A. Shepard, A. A. Franke, T. W. Randolph, L. R. Wilkens, C. J. Boushey, L. Le Marchand, U. Lim, and J. W. Lampe collected the Multiethnic Cohort Study Adiposity Phenotype Study data; M. A. J. Hullar, J. A. Shepard, and A. A. Franke conducted laboratory analyses; T. W. Randolph contributed to statistical analysis plans; C. L. Frankenfeld conducted statistical analyses; C. L. Frankenfeld drafted the manuscript; and C. L. Frankenfeld, M. A. J. Hullar, G. Maskarinec, K. R. Monroe, J. A. Shepard, A. A. Franke, T. W. Randolph, L. R. Wilkens, C. J. Boushey, L. Le Marchand, U. Lim, and J. W. Lampe reviewed the manuscript for content and approved the final manuscript. Byline: Cara L. Frankenfeld, PhD (1), Meredith A.J. Hullar, PhD (2), Gertraud Maskarinec, MD, PhD (3), Kristine R. Monroe, PhD (4), John A. Shepherd (5), Adrian A. Franke, PhD (6), Timothy W. Randolph, PhD (2), Lynne R. Wilkens, DrPH (5), Carol J. Boushey, PhD, MPH, RDN (3), Loïc Le Marchand, MD, PhD (3), Unhee Lim, PhD (5), Johanna W. Lampe, PhD, RD [jlampe@fredhutch.org] (2,*)

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Gale Document Number: GALE|A686979908