Ultrasound-Induced Bubble Clusters in Tissue-Mimicking Agar Phantoms

Citation metadata

From: Ultrasound in Medicine & Biology(Vol. 43, Issue 10)
Publisher: Elsevier B.V.
Document Type: Report
Length: 274 words

Document controls

Main content

Abstract :

To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1016/j.ultrasmedbio.2017.06.013 Byline: Pooya Movahed [pooyam@illinois.edu] (*), Wayne Kreider ([Dagger]), Adam D. Maxwell ([Dagger],[double dagger]), Barbrina Dunmire ([Dagger]), Jonathan B. Freund (s.) Key Words Cavitation; Bubble dynamics; Bubble cluster; Viscoelastic medium; Agar phantom; Burst wave lithotripsy; Tissue injury Abstract Therapeutic ultrasound can drive bubble activity that damages soft tissues. To study the potential mechanisms of such injury, transparent agar tissue-mimicking phantoms were subjected to multiple pressure wave bursts of the kind being considered specifically for burst wave lithotripsy. A high-speed camera recorded bubble activity during each pulse. Various agar concentrations were used to alter the phantom's mechanical properties, especially its stiffness, which was varied by a factor of 3.5. However, the maximum observed bubble radius was insensitive to stiffness. During 1000 wave bursts of a candidate burst wave lithotripsy treatment, bubbles appeared continuously in a region that expanded slowly, primarily toward the transducer. Denser bubble clouds are formed at higher pulse repetition frequency. The specific observations are used to inform the incorporation of damage mechanisms into cavitation models for soft materials. Author Affiliation: (*) Department of Mechanical Science and Engineering, University of Illinois at Urbana--Champaign, Urbana, IL, USA ([Dagger]) Center for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, Seattle, WA, USA ([double dagger]) Department of Urology, University of Washington School of Medicine, Seattle, WA, USA (s.) Department of Aerospace Engineering, University of Illinois at Urbana--Champaign, Urbana, IL, USA * Address correspondence to: Pooya Movahed, 1206 West Green Street, Urbana, IL 61801, USA. Article History: Received 15 February 2017; Revised 17 May 2017; Accepted 15 June 2017

Source Citation

Source Citation   

Gale Document Number: GALE|A553069016