Selenium and Vitamin E Modulates Radiation-Induced Liver Toxicity in Pregnant and Nonpregnant Rat: Effects of Colemanite and Hematite Shielding

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From: Biological Trace Element Research(Vol. 134, Issue 3)
Publisher: Springer
Document Type: Report
Length: 393 words

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Byline: Osman Gencel (1), Mustafa Naziroglu (2), Omer Celik (2), Kadir Yalman (2), Dilek Bayram (3) Keywords: 7-Gy ionizing radiation; Oxidative stress; Glutathione peroxidase; Vitamin E; Colemanite; Hematite; Radiation protection Abstract: The levels of liver lipid peroxidation, glutathione peroxidase, reduced glutathione, and vitamins A and E were used to follow the level of oxidative damage caused by ionizing radiation in pregnant rats. The possible protective effects of selenium and vitamin E supplemented to rats housed in concrete-protected cages using hematite and colemanite were tested and compared to untreated controls. Ninety-six rats were randomly divided into four main equal groups namely control (A), normal concrete (B), concrete containing colemanite (C), and concrete containing hematite (D). Except group A, all groups exposed to 7 Gy radiation. The four main groups were divided into four subgroups each as follows: subgroups 1 (n=6): nonpregnant control rats. Subgroups 2 (n=6): selenium and vitamin E combination was intraperitoneally (i.p.) given to the nonpregnant rats for 20 days. Subgroups 3 (n=6): pregnant control rats. Subgroups 4 (n=6): selenium and vitamin E combination was i.p. given to the pregnant rats for concessive 20 days. Lactate dehydrogenate, alkaline phosphates, and lipid peroxidation values were higher in subgroups 1 and 3 than in no radiation group although glutathione peroxidase and vitamin E levels in liver were lower in radiation group than in no radiation group. Lactate dehydrogenate activity and lipid peroxidation levels were found to be decreased in subgroups 2 and 4 protected with concrete containing hematite and colemanite when compared to subgroup 1 and 3 with normal concrete. The radiation doses in rats housed by concrete without colemanite and hematite exposed radiation clearly showed liver degeneration. In conclusion, selenium and vitamin E supplementations and housing by concrete with colemanite was found to offer protection against gamma-irradiation-induced liver damage and oxidative stress in rats, probably by exerting a protective effect against liver necrosis via its free radical scavenging and membrane stabilizing. Protective effects of colemanite in the liver seem to be more important than in hematite. Author Affiliation: (1) Department of Civil Engineering, Faculty of Engineering, BartA+-n University, BartA+-n, Turkey (2) Department of Biophysic, Medical (TIP) Faculty, Suleyman Demirel University, Morfoloji Binasi, Cunur, 32260, Isparta, Turkey (3) Department of Histology and Embriology, Medical Faculty, Suleyman Demirel University, Isparta, Turkey Article History: Registration Date: 26/08/2009 Received Date: 12/08/2009 Accepted Date: 26/08/2009 Online Date: 18/09/2009

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Gale Document Number: GALE|A231316564