Carbon monoxide reverses adipose tissue inflammation and insulin resistance upon loss of ovarian function

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Publisher: American Physiological Society
Document Type: Author abstract; Report
Length: 164 words

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Abstract :

We hypothesized that carbon monoxide (CO) might suppress chronic inflammation, which led to metabolic disturbances. Ovariectomy (OVX) was performed in mice to mimic chronic inflammation secondary to loss of ovarian function. OVX increased fat mass and the infiltration of highly inflammatory CD11c cells into adipose tissue (AT), resulting in a disturbance of glucose metabolism. Treatment of CO attenuated these; CO decreased recruitment of CD11c-expressing cells in AT and reduced expression of CD 11c in bone marrow-derived macrophages, protecting them from Ml polarization. Upregulated cGMP and decreased reactive oxygen species were responsible for the inhibitory activity of CO on CD 11c expression; knockdown of soluble guanylate cyclase or heme oxygenase-1 using small interfering RNAs reduced this inhibition substantially. Improved OVX-induced insulin resistance (IR) by CO was highly associated with its activity to attenuate AT inflammation. Our results suggest a therapeutic value of CO to treat postmenopausal IR by reducing AT inflammation. loss of ovarian function; carbon monoxide; CD11c; adipose tissue inflammation; insulin resistance doi: 10.1152/ajpendo.00458.2014

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Gale Document Number: GALE|A412119543