Observations of Translation and Jetting of Ultrasound-Activated Microbubbles in Mesenteric Microvessels

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From: Ultrasound in Medicine & Biology(Vol. 37, Issue 12)
Publisher: Elsevier B.V.
Document Type: Article
Length: 206 words

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Abstract :

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ultrasmedbio.2011.09.013 Byline: Hong Chen, Andrew A. Brayman, Wayne Kreider, Michael R. Bailey, Thomas J. Matula Abstract: High-speed photomicrography was used to study the translational dynamics of single microbubbles in microvessels of ex vivo rat mesenteries. The microbubbles were insonated by a single 2 [mu]s ultrasound pulse with a center frequency of 1 MHz and peak negative pressures spanning the range of 0.8-4 MPa. The microvessel diameters ranged from 10-80 [mu]m. The high-speed image sequences show evidence of ultrasound-activated microbubble translation away from the nearest vessel wall; no microbubble showed a net translation toward the nearest vessel wall. Microbubble maximum translation displacements exceeded 20 [mu]m. Microjets with the direction of the jets identifiable were also observed; all microjets appear to have been directed away from the nearest vessel wall. These observations appear to be characteristic of a strong coupling between ultrasound-driven microbubbles and compliant microvessels. Although limited to mesenteric tissues, these observations provide an important step in understanding the physical interactions between microbubbles and microvessels. Author Affiliation: Center for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, Seattle, WA, USA Article History: Received 11 March 2011; Revised 14 September 2011; Accepted 20 September 2011

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Gale Document Number: GALE|A272907601