Dimerization through the RING Finger Domain Attenuates Excision Activity of the piggyback Transposese

The study shows that the RING-finger domain (RFD) present toward the C-terminus of the transposase is vital for dimerization of this enzyme and suggests that dimerization attenuates the excision activity of the piggyBac transposase. This attribute of the piggyBac transposase may serve to prevent excessive transposition of the piggyBac transposon that might be catastrophic for the host cell.