Correlation of Platelet and Coagulation Function with Blood Stasis Syndrome in Coronary Heart Disease: A Systematic Review and Meta-Analysis.

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Date: Nov. 2021
From: Chinese Journal of Integrative Medicine(Vol. 27, Issue 11)
Publisher: Springer
Document Type: Report; Brief article
Length: 378 words

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Keywords: coronary heart disease; blood stasis syndrome; platelet; coagulation Abstract Objective To investigate the correlation of platelet and coagulation function with blood stasis syndrome (BSS) in coronary heart disease (CHD). Methods The protocol for this meta-analysis was registered on PROSPERO (CRD42019129452). PubMed, Excerpta Medica Database (Embase), the Cochrane Library, and China National Knowledge Infrastructure (CNKI) were searched from inception to 1st June, 2020. Trials were considered eligible if they enrolled BSS and non-BSS (NBSS) patients with CHD and provided information on platelet and coagulation function. The platelet function, coagulation function, and fibrinolytic activity were compared between the BSS and NBSS groups. Forest plots were generated to show the SMDs or ESs with corresponding 95% CIs for each study. Subgroup analysis and sensitivity analysis were performed to explore potential sources of heterogeneity. Results The systematic search identified 1,583 articles. Thirty trials involving 10,323 patients were included in the meta-analysis. The results showed that mean platelet volume, platelet distribution width, platelet aggregation rate, platelet P selectin, fibrinogen, plasminogen activator inhibitor-1 (PAI-1), thromboxane B2 (TXB2), 6-keto-prostaglandin F1alpha (6-keto-PGF1 [alpha]), and TXB2/6-keto-PGF1 [alpha] were higher in the BSS group than in the NBSS group (P Conclusions Increased platelet function, hypercoagulability, and decreased fibrinolytic activity were found among CHD patients with BSS. Author Affiliation: (1) Laboratory of Cardiovascular Diseases, Xiyuan Hospital, China Academy of Chinese Medical Sciences, 100091, Beijing, China (2) National Clinical Research Center for Chinese Medicine Cardiology, 100091, Beijing, China (3) Department of Clinical Laboratory, Xiyuan Hospital, China Academy of Chinese Medical Sciences, 100091, Beijing, China (g) Article History: Registration Date: 09/15/2021 Accepted Date: 01/18/2021 Online Date: 09/16/2021 Byline: Qi-qi Xin (1, 2), Xun Chen (3), Rong Yuan (1, 2), Ya-hui Yuan (1, 2), Jia-qi Hui (1, 2), Yu Miao (1, 2), Wei-hong Cong (corresponding author) (1, 2, g), Ke-ji Chen (1, 2)

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Gale Document Number: GALE|A681341750