Abstract :
Keywords High-risk infants; Moderate-late preterm birth; Motor optimality; General movement assessment Highlights * Infants born moderate-late preterm had higher Motor Optimality Scores compared to infants with high risk * Infants born with high-risk were more likely to have aberrant general movements than those born moderate-late preterm * A history of periventricular leukomalacia, VP shunt, or bronchopulmonary dysplasia was associated with lowered MOS-R score Abstract Background The Motor Optimality Score-Revised (MOS-R) is a detailed scoring of the General Movement Assessment (GMA), measuring the spontaneous behaviors of infants. Infants born moderate-late preterm are not traditionally followed in high-risk clinics, but have increased risk of neurodevelopmental disability. Aims Compare MOS-R at 3 months corrected age (CA) in high-risk (HR; very preterm or abnormal neuroimaging) infants to infants born moderate-late preterm (MLP). Study design In this prospective cohort study, parents of enrolled infants created video recordings using an app at 3 months CA. Videos were scored with the General Movement Assessment (GMA) and MOS-R. MOS-R scores were divided into "higher-risk" ([less than or equal to]19) and "lower-risk" ([greater than or equal to]20). Subjects 181 infants born MLP or categorized as HR. Results Among enrolled infants, 68 (38 %) were in the MLP group, and 113 infants were in the HR group. The HR group had 3.8 increased odds of having an aberrant GMA score compared to the MLP group (p Conclusions Aberrant GMA and higher-risk MOS-R scores were more common in infants at high-risk, reflecting history of brain lesions and younger gestational age at birth. Abbreviations MOS-R, Motor Optimality Score Revised; GMA, General Movement Assessment; FM, fidgety movements; HR, high-risk; MLP, moderate-late preterm Author Affiliation: (a) Department of Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, 645 N Michigan Ave, Suite 1100, Chicago, IL 60611, USA (b) Department of Pediatrics, Feinberg School of Medicine, Northwestern University, 645 N Michigan Ave, Suite 1100, Chicago, IL 60611, USA (c) Department of Ophthalmology and Visual Science, University of Chicago, 5841 S. Maryland Ave, Chicago, IL 60637, USA (d) Ann and Robert H Lurie Children's Hospital, 225 E Chicago Ave, Chicago, IL 60611, USA (e) Loyola University Medical Center, 2160 S. 1st Ave, Maywood, IL 60153, USA (f) Victorian Infant Brain Studies (VIBeS), Murdoch Children's Research Institute, 50 Flemington Rd, Parkville, VIC 3052, Australia (g) University of Illinois Health, 1740 W Taylor St, Chicago, IL 60612, USA * Corresponding author at: 645 N. Michigan Ave, Suite 1100, Chicago, IL 60611, USA. Article History: Received 22 August 2022; Revised 27 September 2022; Accepted 28 September 2022 Byline: Colleen Peyton [colleen.peyton1@northwestern.edu] (a,b,*), Ryan Millman (a), Sarah Rodriguez (c), Lynn Boswell (d), Meg Naber (e), Alicia Spittle (f), RayeAnn de Regnier (b,d), Vanessa Maziero Barbosa (g), Theresa Sukal-Moulton (a,b)