Boiling histotripsy method to mechanically fractionate tissue volumes in ex vivo bovine liver using a clinical MR-guided HIFU system

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From: Journal of Therapeutic Ultrasound(Vol. 3, Issue Suppl 1)
Publisher: BioMed Central Ltd.
Document Type: Article
Length: 643 words
Lexile Measure: 1480L

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Author(s): Vera Khokhlova1 , Ari Partanen2 , Adam Maxwell1 , Tatiana Khokhlova1 , Wayne Kreider1 , Michael Bailey1 , Navid Farr1 , Yak-Nam Wang1 , George Schade1 and Oleg Sapozhnikov3

Background/introduction

Most current HIFU approaches to treat liver tumors rely on thermal tissue ablation. Challenges still remain that prevent widespread clinical application of this technology including long treatment times, side effects such as skin burns, attenuation and aberration by ribs, heat diffusion and perfusion. Recently, a new method named boiling histotripsy (BH) was developed at the UW/MSU to address these challenges. BH applies a sequence of millisecond-long pulses with high-amplitude shocks that rapidly heat tissue and initiate boiling within each pulse. Interaction of shocks with the resulting vapor cavity leads to tissue fractionation into subcellular debris. Multiple BH lesions can be generated to sonicate clinically relevant tissue volumes. The goal of this study was to evaluate the feasibility of a clinical HIFU system to treat tissue with BH...

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Gale Document Number: GALE|A541671536