The Fifth Domain in the G-Quadruplex - Forming Sequence of he Human NEIL3 Promoter Locks DNA Folding in Response to Oxidative Damage

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Date: May 22, 2018
From: Biochemistry(Vol. 57, Issue 20)
Publisher: American Chemical Society
Document Type: Report
Length: 71 words

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Abstract :

The study shows the G-rich promoter region of the human NEIL3 gene to fold into a dynamic G-quadruplex (G4) structure under nearly physiological conditions using spectroscopic techniques and DNA polymerase stop assays and further identifies the NEIL3 promoter possessing a G-rich element that can adopt a G4 fold, and when OG is incorporated, the sequence can lock into a more stable G4 fold via recruitment of the fifth track of Gs.

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Gale Document Number: GALE|A542243000