Combination of Activating Blood Circulation and Detoxifying Chinese Medicines Played an Anti-Inflammatory Role in Unstable Angina Patients after Percutaneous Coronary Intervention: A Multicenter, Open-Labeled, Randomized Controlled Trial.

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From: Chinese Journal of Integrative Medicine(Vol. 27, Issue 11)
Publisher: Springer
Document Type: Clinical report; Brief article
Length: 376 words

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Keywords: Chinese medicine; unstable angina; inflammation; randomized controlled trial Abstract Objective To investigate the combined anti-inflammatory effect of activating blood circulation and detoxifying Chinese medicines in unstable angina (UA) patients. Methods This study was an open-labeled, randomized controlled trial conducted in 5 centers in Beijing. A total of 154 patients were randomized into two groups at a 1:1 ratio by random numbers. Based on the conventional treatment, patients in the activating blood circulation (ABC) group were treated with Guanxin Danshen Droping Pill (å å¿ä¸¹å滴丸, 0.4 g, thrice daily), and patients in the activating blood circulation and detoxifying (ABCD) group were treated with Guanxin Danshen Droping Pill (0.4 g, thrice daily) and Andrographis tablet (0.2 g, thrice daily) for 4 weeks. The primary outcome was the serum level of high sensitive C reaction protein (hs-CRP), and the secondary outcome index included the serum levels of tumor necrosis factor [alpha] (TNF-[alpha]), interleukin 6 (IL-6), soluble CD40 ligand (sCD40L), thrombomodulin (TM), the score of angina pectoris, the score of blood stasis syndrome, and the score of Chinese medicine symptoms, observed at week 0 and week 4. Results A total of 144 patients completed the trial (ABC group, n=70 ABCD group, n=74). There were no significant differences in the clinical baseline characteristics between the two groups. When compared with the ABC group, ABCD group showed better performance in reducing the level of inflammatory factors, especially hs-CRP (P Conclusions The combination of Guanxin Danshen Dropping Pill and Andrographis tablet exert significant anti-inflammatory effect on UA patients, which is superior to single Guanxin Danshen Dropping Pill. (Registration No. ChiCTR-TRC-13004072) Author Affiliation: (1) National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, 100091, Beijing, China (2) Cardiovascular Diseases Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences, 100091, Beijing, China (g) shidztcm@163.com Article History: Registration Date: 09/15/2021 Accepted Date: 02/22/2021 Online Date: 09/16/2021 Byline: Xiao-juan Ma (1, 2), Wen-hui Duan (1, 2), Ying Zhang (1, 2), Jie Gao (1, 2), Bao-yi Guan (1, 2), Ke-ji Chen (1, 2), Da-zhuo Shi (corresponding author) (1, 2, g)

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Gale Document Number: GALE|A681341753