Microfluidic platform with in-chip electrophoresis coupled to mass spectrometry for monitoring neurochemical release from nerve cells

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Date: May 17, 2016
From: Analytical Chemistry(Vol. 88, Issue 10)
Publisher: American Chemical Society
Document Type: Report
Length: 60 words

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Abstract :

A three-layered microfluidic chip is fabricated and evaluated for studying the dynamics of neurotransmitter release from PC-12 cells. Monitoring neurotransmitter release from PC-12 cells exposed to KCl (or alcohol) reveals that all four neurotransmitters investigated are released. These results suggest that DA and 5-HT are packaged into different vesicle pools and they are mobilized differently in response to chemical stimuli.

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Gale Document Number: GALE|A456330597