Time-dependent inhibition of isoprenylcysteine carboxyl methytransferase by indole-based small molecules

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From: Biochemistry(Vol. 46, Issue 2)
Publisher: American Chemical Society
Document Type: Article
Length: 52 words

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Abstract :

A study was conducted to establish the kinetic characteristics of cysmethynil, which act as a classical time-dependent inhibitor of isoprenylcysteine carboxyl methyltransferase (Icmt). Findings reveal that cysmethynil is a competitive inhibitor with respect to the isoprenylated cysteine substrate and a noncompetitive inhibitor with respect to AdoMet the methyl donor in the reaction.

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Gale Document Number: GALE|A159305908