Chinese Medicine Involving Triple Rehabilitation Therapy for Knee Osteoarthritis in 696 Outpatients: A Multi-Center, Randomized Controlled Trial.

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From: Chinese Journal of Integrative Medicine(Vol. 27, Issue 10)
Publisher: Springer
Document Type: Report
Length: 482 words

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Keywords: knee osteoarthritis; Chinese medicine involving triple rehabilitation therapy; electro-acupuncture; Chinese medicinal herb fumigating-washing; traditional exercises; community rehabilitation Abstract Objective To determine the effects of Chinese medicine (CM) involving triple rehabilitation therapy on the progression of knee osteoarthritis (KOA). Methods A total of 722 patients recruited from 38 community health service centers located in China from March 2013 to March 2017 were randomly divided into treatment and control groups equally, using a cluster randomization design. Health education combined with CM involving triple rehabilitation therapy for KOA (electro-acupuncture, Chinese medicinal herb fumigating-washing, and traditional exercises) was administered in the treatment group while conventional rehabilitation therapy (physical factor therapy, joint movement training, and muscle strength training) was administered in the control group. Patients with a visual analog scale (VAS) scores â½4 were treated with dispersible meloxicam tablets (7.5 mg, once daily). The Lequesne index scores, VAS scores, range of motion (ROM), lower limb muscle strength, knee joint circumference, quantitative scores of KOA symptoms, and the short-form 36 item health survey questionnaire (SF-36) scores were measured for each patient at 5 checkpoints (before treatment, at the 2nd week and the 4th week during the 4-week treatment period, at 1 month and 3 months after end of treatment), and adverse reactions were observed also. Results A total of 696 patients completed the entire process, with 351 in the treatment group and 345 in the control group. At all treatment checkpoints, the treatment group demonstrated better outcomes than the control group with regard to the total Lequesne index scores, effective rate and improvement rate of the total Lequesne index scores, VAS scores, lower limb muscle strength, knee circumference, quantitative scores of KOA symptoms, and SF-36 scores as well (P Conclusions CM involving triple rehabilitation therapy can alleviate KOA-related pain and swelling, improve lower limb muscle strength, promote flexion and activity of the knee and improve the quality of life in patients undergoing KOA. It is suitable for patients with early or mid-stage KOA. (Registration No. ChiCTR-TRC-12002538) Author Affiliation: (1) Department of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, 350122, Fuzhou, China (2) Department of Clinical Medicine, Fujian Health College, 350101, Fuzhou, China (3) Department of Traditional Chinese Medicine, Fujian University of Traditional Chinese Medicine, 350122, Fuzhou, China (4) Department of Rehabilitation, Fujian Tingzhou Hospital, 366300, Longyan, Fujian Province, China (5) Department of Emergency, Xiaogan Chinese Medicine Hospital, 432100, Xiaogan, Hubei Province, China (6) Department of Rehabilitation, Fuzhou First Hospital, 350009, Fuzhou, China (7) Fujian University of Traditional Chinese Medicine, 350122, Fuzhou, China (n) suyouxin777@hotmail.com Article History: Registration Date: 03/11/2021 Accepted Date: 12/04/2020 Online Date: 03/12/2021 Byline: Jie-mei Guo (1, 2), Yan Xiao (1), Tang-yan Cai (2), Jian-hui Wang (1), Bao-lin Li (3), Lu-lu Huang (1), Xiao Mao (3), Xing-quan Lai (4), Ya-ju Zhu (5), Yi-qiang Zhang (6), Shao-qing Chen (1), You-xin Su (corresponding author) (7, n)

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Gale Document Number: GALE|A681422107