The effectiveness of acupuncture for Parkinson's disease: An overview of systematic reviews.

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Publisher: Elsevier B.V.
Document Type: Report
Length: 502 words

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Keywords Acupuncture; Parkinson's disease; Overview; Systematic review Highlights * We assessed the methodological quality of SRs/MAs with the AMSTAR 2 tool, and the GRADE approach to quantify the quality of evidence. * We established strict inclusion criteria, used comprehensive search strategies to ensure that all relevant SRs/MAs were identified. * We only included systematic reviews of randomized trials to reduce the risk of bias. * Meta-analysis of acupuncture on patients with Parkinson's disease. Abstract Objectives Acupuncture is an alternative therapy for Parkinson's disease (PD), but its efficacy and safety are controversial. This overview aimed to summarize the existing evidence from systematic reviews (SRs) and meta-analyses (MAs) in order to assess the effectiveness of acupuncture as a treatment for PD. Methods Seven electronic databases were searched from their inception until July 2019. The Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) and Assessment of Multiple Systematic Reviews 2 (AMSTAR2) checklists were used to assess evidence quality and methodological quality, respectively. The outcomes of study were calculated using mean differences (MDs) and risk ratios (RRs) with 95 % confidence intervals (CIs). A meta-analysis was performed using RevMan 5.3 software. Results A total of 12 SRs/MAs were included. All 12 SRs/MAs had more than one critical weakness in AMSTAR 2 and were considered of critically low methodological quality. The quality of evidence was unsatisfactory according to the GRADE checklist. Meta-analyses showed that acupuncture combined with drug for the treatment of PD can significantly improve the total effectiveness rate compared with drug alone (RR = 1.25, 95 % CI 1.16--1.34, P Conclusion Acupuncture might improve the UPDRS score, Webster score, and total effective rate in treatment of PD. It might be a safe and useful adjunctive treatment for patients with PD. However, we should interpret the findings of these reviews with caution, considering the overall limited methodological and reporting quality. Author Affiliation: (a) School of Public Health, Lanzhou University, Lanzhou 730000, China (b) Evidence Based Social Science Research Center, Lanzhou University, Lanzhou 730000, China (c) Key Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu Province, Lanzhou 730000, China (d) Evidence Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China (e) Chinese Medicine Faculty of Hong Kong Baptist University, Hong Kong (f) Gansu University of Chinese Medicine, Lanzhou 730000, China (g) The First Clinical Medical College, Lanzhou University, Lanzhou 730000, China * Corresponding author at: Evidence-Based Medicine Center, Lanzhou University, 199 Donggang West Road, Lanzhou, China. Article History: Received 29 October 2019; Revised 1 February 2020; Accepted 11 March 2020 (footnote)1 Liujiao Cao and Xiuxia Li are co-first authors. Byline: Liujiao Cao (a,b,c,d,1), Xiuxia Li (a,b,c,d,1), Meixuan Li (a,b,c,d), Liang Yao (e), Liangying Hou (a,b,c,d), Weiyi Zhang (a,b,c,d), Yongfeng Wang (f), Junqiang Niu [niujunqiang2020@126.com] (g), Kehu Yang [kehuyangebm2006@126.com] (a,b,c,d)

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Gale Document Number: GALE|A624909591