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Date: Aug. 2013
Publisher: Expert Reviews Ltd.
Document Type: Report
Length: 688 words
Lexile Measure: 1220L

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Infection with Clostridium difficile causes more than 7000 deaths annually and is the most commonly diagnosed cause of antibiotic-associated diarrhoea. Hospital-acquired C. difficile infection is on the rise with the bacteria prevalent in many hospitals throughout Europe. Studies estimate there is a mean frequency of 23 cases for every 10,000 admissions. Current research is focusing on finding modifiable risk factors for infection in the hope of developing better preventative and therapeutic options in the battle against the bacteria.

Previous research has demonstrated several classes of medication to be a risk factor for C. difficile infection including antidepressant medications. Such a link is particularly important as depression is now the most prevalent disabling condition worldwide. Links have also been demonstrated between depression, alterations in gut microbiota and increased intestinal permeability both in murine and human studies. Since preliminary links were made between C. difficile infection and antidepressants, little evidence has come to light to confirm or refute these findings. A recently published study in BMC Medicine set out to discover more.

The aim...

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Gale Document Number: GALE|A341859533