Higher plasma drug levels in elderly people living with HIV treated with darunavir

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From: PLoS ONE(Vol. 16, Issue 2)
Publisher: Public Library of Science
Document Type: Report
Length: 4,740 words
Lexile Measure: 1380L

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Abstract :

Background The proportion of elderly people living with HIV-1 (PLHIV) is rising. In older patients, comorbidities and concomitant medications are more frequent, increasing the risk of potential drug-drug interactions (PDDIs). Data on the pharmacokinetics of ART in individuals aged [greater than or equal to] 65 years of age are scarce. We compared plasma drug levels of ART, PDDIs, and side-effects in PLHIV aged [greater than or equal to] 65 years of age, with controls [less than or equal to] 49 years of age. Methods Patients [greater than or equal to] 65 years of age and controls [less than or equal to] 49 years of age, all of whom were on stable treatment with atazanavir (ATV), darunavir (DRV), or efavirenz (EFV) were included cross-sectionally. Plasma drug levels of ART were analyzed, comorbidities, concomitant medication, adherence, and side-effects recorded, and PDDIs analyzed using drug interactions databases. Results Between 2013 and 2015, we included 100 individuals [greater than or equal to] 65 years of age (study group) and 99 controls ([less than or equal to] 49 years of age). Steady-state DRV concentrations were significantly higher in the study group than in the control group (p = 0.047). In the ATV group there was a trend towards a significant difference (p = 0.056). No significant differences were found in the EFV arm. The DRV arm had a higher frequency of reported side-effects than the ATV and EFV arms in the study group (36.7% vs. 0% and 23.8% respectively (p = 0.014), with significant differences between DRV vs. ATV, and EFV vs. ATV). Conclusions Higher steady-state plasma levels of DRV and ATV (but not EFV) were found in PLHIV aged [greater than or equal to] 65 years of age, compared to controls [less than or equal to] 49 years of age.

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Gale Document Number: GALE|A650730672