The electroretinogram as a method for studying circadian rhythms in the mammalian retina

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Date: Dec. 2008
From: Journal of Genetics(Vol. 87, Issue 3)
Publisher: Springer
Document Type: Report
Length: 179 words

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Abstract :

Byline: Morven A. Cameron (1), Alun R. Barnard (2), Robert J. Lucas (1) Keywords: electroretinogram (ERG); retina; circadian; rhythm; melanopsin Abstract: Circadian clocks are thought to regulate retinal physiology in anticipation of the large variation in environmental irradiance associated with the earth's rotation upon its axis. In this review we discuss some of the rhythmic events that occur in the mammalian retina, and their consequences for retinal physiology. We also review methods of tracing retinal rhythmicity in vivo and highlight the electroretinogram (ERG) as a useful technique in this field. Principally, we discuss how this technique can be used as a quick and noninvasive way of assessing physiological changes that occur in the retina over the course of the day. We highlight some important recent findings facilitated by this approach and discuss its strengths and limitations. Author Affiliation: (1) Faculty of Life Sciences, University of Manchester, A. V. Hill Building, Manchester, M13 9PT, UK (2) Neurobehaviour Group, MRC Harwell, Harwell, Didcot, Oxfordshire, OX11 0RD, UK Article History: Registration Date: 26/01/2008 Received Date: 23/09/2008 Accepted Date: 05/11/2008 Online Date: 31/12/2008

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Gale Document Number: GALE|A231379236