Isoindole Linkages Provide a Pathway for DOPAL-Mediated Cross-Linking of [alpha]-Synuclein

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From: Biochemistry(Vol. 57, Issue 9)
Publisher: American Chemical Society
Document Type: Report
Length: 42 words

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Abstract :

The article presents the study of 3,4-Dihydroxyphenylacetaldehyde (DOPAL) cross-links [alpha]-synuclein molecules of dicatechol isoindole lysine (DCIL) forms intermolecular carbon-carbon bond. Topics include isotopic labeling approach to show predominant cross-linking mechanism reveals interadduct reaction pathways of catechol-based oxidative protein damage to separable atropisomers.

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Gale Document Number: GALE|A534791109