Genital chlamydial infection in STD patients: Its relation to HIV infection

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Date: January-March 2005
From: Indian Journal of Medical Microbiology(Vol. 23, Issue 1)
Publisher: Elsevier B.V.
Document Type: Article
Length: 1,539 words

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Byline: A. Joyee, S. Thyagarajan, E. Reddy, C. Venkatesan, M. Ganapathy

In the present report, we have analysed C.trachomatis infection and HIV positivity among patients (n-143) who attended the STD clinic at the Institute of STDs, Government General Hospital, Chennai. HIV positivity rate was significantly high among those with chlamydial infection than in those without chlamydial infection (29.5% (13/44) vs. 11.1% (11/99); p< 0.05). The results of the present study suggest the association between C.trachomatis and HIV infections and reinforce the need for routine screening for C.trachomatis as a necessary intervention to reduce the burden of chlamydial diseases and to reduce the risk of HIV and its spread in India.

Genital infection due to Chlamydia trachomatis (CT) is currently the most prevalent among the bacterial STDs.[1] C.trachomatis infection, if undiagnosed and untreated, can result in pelvic inflammatory disease (PID), epidydimitis etc., finally damaging the human reproductive tract irreversibly. The health costs due to the destructive clinical sequelae caused by C.trachomatis infection is enormous. Further to this, growing evidence points that active C.trachomatis infection is an important risk factor facilitating sexual transmission of HIV infection.[2],[3] Hence, documentation of C.trachomatis infections in high-risk populations can assist in designing HIV-risk reduction strategies as well. In this report, we have analysed the infection rates of genital chlamydial infection and HIV infection and the possible association between the two infections.

Materials and Methods

Symptomatic men and women patients (n=143) attending the STD out patient clinic at the Institute of STDs, Government General hospital, Chennai, were enrolled in the study during the period of September 1998 to August 2000. The study was approved by the Ethics committee of Govt. General Hospital. A written informed consent was obtained from each patient and detailed history, demographical and clinical features were recorded. Blood samples and genital swab specimens were obtained from each patient. Urethral and endocervical swabs were collected from males and females respectively, placed in 0.2M sucrose phosphate (2SP) transport medium and were used for both chlamydial culture and PCR assays.

The serum samples were subjected for the detection of IgG specific antibodies to C.trachomatis by using a commercial immunoperoxidase assay kit (IPAzyme Chlamydia , Savyon diagnostics, Israel). Culture for C.trachomatis was performed on cycloheximide treated McCoy cells. Aliquots of 2SP specimens were tested initially by a plasmid PCR assay and further...

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Gale Document Number: GALE|A132355135