Update of Ablative Fractionated Lasers to Enhance Cutaneous Topical Drug Delivery

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From: Advances in Therapy(Vol. 34, Issue 8)
Publisher: Springer
Document Type: Report
Length: 359 words

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To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1007/s12325-017-0516-9 Byline: Jill S. Waibel (1), Ashley Rudnick (1), Deborah R. Shagalov (2), Danielle M. Nicolazzo (3) Keywords: Delivery; Drug; Energy device; Laser; Systematic Abstract: Ablative fractional lasers (AFXL) enhance uptake of therapeutics and this newly emerging field is called laser-assisted drug delivery (LAD). This new science has emerged over the past decade and is finding its way into clinical practice. LAD is poised to change how medicine delivers drugs. Topical and systemic application of pharmaceutical agents for therapeutic effect is an integral part of medicine. With topical therapy, the stratum corneum barrier of the skin impairs the ability of drugs to enter the body. The purpose of LAD is to alter the stratum corneum, epidermis, and dermis to facilitate increased penetration of a drug, device, or cell to its respected target. AFXL represents an innovative, non-invasive strategy to overcome the epidermal barrier. LAD employs three steps: (1) breakdown of the skin barrier with a laser, (2) optional use a laser for a therapeutic effect, (3) delivery of the medicine through laser channels to further enhance the therapeutic effect. The advantages of using lasers for drug delivery include the ease of accessibility, the non-invasive aspect, and its effectiveness. By changing the laser settings, one may use LAD to have a drug remain locally within the skin or to have systemic delivery. Many drugs are not intended for use in the dermis and so it has yet to be determined which drugs are appropriate for this technique. It appears this developing technology has the ability to be a new delivery system for both localized and systemic delivery of drugs, cells, and other molecules. With responsible development AFXL-assisted drug delivery may become a new important part of medicine. Author Affiliation: (1) Miami Dermatology and Laser Institute, Miami, FL, USA (2) Dermatology, State University of New York, Downstate Medical Center, Brooklyn, NY, USA (3) Dermatology, Larkin Hospital/NSU-COM, South Miami, FL, USA Article History: Registration Date: 10/03/2017 Received Date: 25/08/2016 Online Date: 07/07/2017 Article note: Enhanced Content To view enhanced content for this article go to http://www.medengine.com/Redeem/E7F7F0600C722D06.

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Gale Document Number: GALE|A501378192