Comparative Effectiveness of Pharmacological Interventions for Covid-19: A Systematic Review and Network Meta-Analysis.

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Publisher: Frontiers Research Foundation
Document Type: Article
Length: 502 words
Lexile Measure: 1370L

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Author(s): Franco De Crescenzo, Laura Amato, Fabio Cruciani, Luke P Moynihan, Gian Loreto D'Alà², Simona Vecchi, Rosella Saulle, Zuzana Mitrova, Valeria Di Franco, Antonio Addis, Marina Davoli

<bold>Background:</bold> Several pharmacological interventions are now under investigation for the treatment of Covid-19, and the evidence is evolving rapidly. Our aim is to assess the comparative efficacy and safety of these drugs.

<bold>Methods and Findings:</bold> We performed a systematic review and network meta-analysis searching Medline, Pubmed, Embase, Cochrane Covid-19 register, international trial registers, medRxiv, bioRxiv, and arXiv up to December 10, 2020. We included all randomised controlled trials (RCTs) comparing any pharmacological intervention for Covid-19 against any drugs, placebo or standard care (SC). Data extracted from published reports were assessed for risk of bias in accordance with the...

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Gale Document Number: GALE|A660540256