Efficacy comparison of chlorhexidine and iodine preparation in reduction of surgical site infection: A systemic review and meta-analysis.

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Authors: Li Li, Yu Wang and Shouyan Wang
Date: Mar. 2022
Publisher: Elsevier B.V.
Document Type: Report; Brief article
Length: 318 words

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Keywords Chlorhexidine; Povidone-iodine; Site infection; General surgery Abstract Background Chlorhexidine and povidone-iodine are the most common disinfectants used in preoperative skin preparation. However, there is no consistent conclusion regarding the prevention of surgical site infection (SSI) and bacterial culture data. Objective To assess the efficacy of chlorhexidine and povidone-iodine in the prevention of postoperative SSI and relevant bacterial data. Design Systematic Review and Meta-Analysis Settings N/A Participants N/A Method Literature relevant to "skin antisepsis" and "surgical site infections" was retrieved from PUBMED, Web of Science, EMBASE, CINHAL and CNKI. The incidence of SSI was the primary outcome, while the secondary outcome was bacterial data from the infected incision. All data were analyzed with Revman 5.3 and Stata Statistical Software. Results A total of 36 studies were identified in this study, which included 16,872 participants. This study revealed that chlorhexidine is superior to povidone-iodine in the prevention of postoperative SSI (risk ratio [RR], 0.73; 95% confidence interval [CI], 0.61--0.87; p = 0.019, I.sup.2 = 39%). Further meta-regression analysis revealed that the effect of chlorhexidine was directly associated with the type of incision, but failed to differentiate between the subgroups divided according to the type of incision. With respect to bacteria colonization, the most common bacteria for chlorhexidine arm were propionibacterium's, while the most common bacteria for the iodine arm were staphylococci species. Conclusion In comparison to povidone-iodine, chlorhexidine showed better results in preventing postoperative SSI. Author Affiliation: (a) Clean Operating department, Harbin Medical University Cancer Hospital, Harbin City, Heilongjiang Province, China (b) The Image Center, Harbin Medical University Cancer Hospital, Harbin City, Heilongjiang Province, China * Corresponding author at: 150 Haping Road, Nangang District, Harbin City, Heilongjiang Province, China. Article History: Received 10 August 2020; Revised 28 July 2021; Accepted 2 August 2021 (footnote)1 Li Li and Shouyan Wang are co-first authors that contributed equally to this work. Byline: Li Li (a,1), Yu Wang [u20952013@163.com] (b,*), Shouyan Wang (a,1)

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Gale Document Number: GALE|A695646040