Impact of smoking and thiocyanate on perchlorate and thyroid hormone associations in the 2001-2002 National Health and Nutrition Examination Survey

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Date: Sept. 2007
From: Environmental Health Perspectives(Vol. 115, Issue 9)
Publisher: National Institute of Environmental Health Sciences
Document Type: Clinical report
Length: 6,570 words
Lexile Measure: 1500L

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Abstract :

BACKGROUND: Findings from a recent large study suggest that perchlorate at commonly occurring exposure concentrations may decrease thyroid hormone levels in some women. Decreases in thyroid hormone seen with perchlorate exposure could be even greater in people with concomitant exposure to agents such as thiocyanate that may affect the thyroid by mechanisms similar to those of perchlorate. OBJECTIVES AND METHODS: We used data from the National Health and Nutrition Examination Survey to assess the impact of smoking and thiocyanate on the relationship between urinary perchlorate and serum thyroxine ([T.sub.4]) and thyroid-stimulating hormone (TSH). RESULTS: In women with urinary iodine levels CONCLUSIONS: These results suggest that thiocyanate in tobacco smoke and perchlorate interact in affecting thyroid function, and this effect can take place at commonly occurring perchlorate exposures. Agents other than tobacco smoke might cause similar interactions, and further research on these agents could help identify people who are particularly susceptible to perchlorate. KEY WORDS: cotinine, interactions, iodine, perchlorate, thiocyanate, thyroid, tobacco smoke. Environ Health Perspect 115:1333-1338 (2007). doi:10.1289/ehp.10300 available via http://dx.doi.org/ [Online 9 July 2007]

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Gale Document Number: GALE|A170115589