Antibacterial, cytotoxic studies and characterization of some newly synthesized symmetrical [N.sup.3], [N.sup.3]'-Bis(disubstituted)isophthalyl-bis(thioureas) and their Cu(II) and Ni(II) complexes

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From: Journal of Chemistry(Vol. 2014)
Publisher: Hindawi Limited
Document Type: Report
Length: 4,415 words
Lexile Measure: 1210L

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Abstract :

A series of some novel [N.sup.3],[N.sup.3];-bis(disubstituted)isophthalyl-bis(thioureas) compounds with general formula [[C.sub.6][H.sub.4] x [{CONHCSNHR}.sub.2]], where R = 2-Cl[C.sub.6][H.sub.4]S ([L.sup.1]), 3,5-[(Cl).sub.2][C.sub.6][H.sub.3] ([L.sup.2]), 2,4-[(Cl).sub.2][C.sub.6][H.sub.3] ([L.sup.3]), 2,5-[(Cl).sub.2][C.sub.6][H.sub.3] ([L.sup.4]), and 2-N[H.sub.2][C.sub.6][H.sub.4] ([L.sup.5]), and their Cu(II) and Ni(II) complexes ([C.sup.1]-[C.sup.10]) have been synthesized. These compounds ([L.sup.1]- [L.sup.5]) and their metal(II) complexes ([C.sup.1]-[C.sup.10]) have been characterized by elemental analysis, infrared spectroscopy, [sup.1]H NMR and [sup.13]C NMR spectroscopy, magnetic moments, and electronic spectral measurements. The ligands are coordinated to metal atom in a bidentate pattern producing a neutral complex of the type [[ML].sub.2]. These compounds ([L.sup.1] -[L.sup.5]) and their metal(II) complexes ([C.sup.1]-[C.sup.10]) were also screened for their antibacterial and cytotoxic activities.

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Gale Document Number: GALE|A417105470