Activity of Topotecan toward the DNA/Topoisomerase I Complex: A Theoretical Rationalization

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From: Biochemistry(Vol. 57, Issue 9)
Publisher: American Chemical Society
Document Type: Report
Length: 42 words

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Abstract :

The article discusses DNA/topoisomerase I (DNA/TopoI) complex by intercalating topotecan (TPT) nontoxic anticancer drug characterized by a pH-dependent lactone/carboxyl equilibrium. Topics include molecular dynamic simulations, quantum mechanical/molecular mechanical calculations, and topological analysis inhibits supercoil relaxation stable interaction between DNA and protein residues.

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Gale Document Number: GALE|A534791345