Human Oxoguanine Glycosylase 1 Removes Solution Accessible 8-Oxo-7,8-dihydroguanine Lesions from Globally Substituted Nucleosomes Except in the Dyad Region

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Date: Mar. 6, 2018
From: Biochemistry(Vol. 57, Issue 9)
Publisher: American Chemical Society
Document Type: Report
Length: 50 words

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Abstract :

The article presents the study of oxoguanine glycosylase (hOGG1 in humans) activity damages guanine lesion 8-oxo-7, 8-dihydroguanine (8-oxoG) responsible for mutagenesis, aging, and disease. Topics include synthetic methods to generate a population of nucleosome core particle (NCP) accessible by hydroxyl radical footprinting (HRF) unwrapping to the dyad axis DNA transient.

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Gale Document Number: GALE|A534790684