Abstract :
The article presents the study of oxoguanine glycosylase (hOGG1 in humans) activity damages guanine lesion 8-oxo-7, 8-dihydroguanine (8-oxoG) responsible for mutagenesis, aging, and disease. Topics include synthetic methods to generate a population of nucleosome core particle (NCP) accessible by hydroxyl radical footprinting (HRF) unwrapping to the dyad axis DNA transient.