Examining Associations Between Dietary Inflammatory Index in Pregnancy, Pro-inflammatory Cytokine and Chemokine Levels at Birth, and Offspring Asthma and/or Wheeze by Age 4 Years.

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Publisher: Elsevier Science Publishers
Document Type: Clinical report; Medical condition overview
Length: 696 words

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Keywords Dietary inflammatory index; Asthma; Cytokines Abstract Background Few studies have demonstrated associations between maternal dietary inflammatory index (DII) during pregnancy and offspring asthma and/or wheeze. Objective The study aimed to assess associations between maternal DII during pregnancy and 1) offspring cord sera pro-inflammatory cytokines (interleukin [IL]-1[beta], IL-4, IL-6, IL-10, tumor necrosis factor-[alpha]) and chemokines (IL-8, monocyte chemoattractant protein-1) at birth and 2) offspring asthma and/or wheeze at age 4 years. Design The Healthy Start study is a prospective prebirth longitudinal study that recruited pregnant women in Denver, Colorado and tracked their offspring. Participants and setting This study used data from 1228 mother-child dyads enrolled in the Healthy Start study. Pregnant women were recruited in Denver, Colorado, between 2009 and 2014, and offspring tracked until age 4 years. Main outcome measures Cord sera cytokines and chemokines were analyzed with multiplex panel immunoassays. Offspring diagnosis of asthma and/or wheeze by age 4 years was extracted from electronic medical records. Statistical analyses performed Unadjusted and adjusted linear and logistic regression models were used to assess associations. Covariates included factors such as nulliparity, race/ethnicity, gestational smoking, and maternal history of asthma. Results Unadjusted analysis showed that increasing maternal DII scores were associated with increased odds of child asthma and/or wheeze by 4 years (odds ratio = 1.17; 95% CI: 1.07-1.27), but the association was attenuated and no longer statistically significant in the adjusted model (odds ratio = 1.15; 95% CI: 0.99-1.33). There were no significant associations between DII scores and cord sera cytokine or chemokine levels. Conclusions The study showed that the inflammatory profile of the maternal diet was not associated with cytokines and chemokine levels at birth. The results suggested that a more inflammatory maternal diet was associated with increased odds of offspring asthma and/or wheeze by age 4 years, which could be considered of clinical relevance but the finding was not statistically significant at the .05 level. Author Affiliation: (1) Children's Hospital Colorado, Aurora (2) University of Colorado Anschutz Medical Campus, Aurora (3) University of Colorado School of Medicine, Aurora (4) Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Aurora (5) Department of Pediatrics, University of Colorado School of Medicine, Aurora (6) Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, Aurora, CO (7) Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora (8) LEAD Center, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora (9) University College Cork, Cork, Ireland (10) University of Colorado, Aurora (11) Colorado School of Public Health, Anschutz Medical Campus, Aurora * Address correspondence to: Carina Venter, PhD, RD, Children's Hospital Colorado, 13123 East 16th Avenue, Box B518, Anschutz Medical Campus, Aurora, CO 80045. Article History: Received 1 July 2020; Accepted 16 February 2021 (footnote) Supplementary materials: The and are available at www.jandonline.org(http://www.jandonline.org). (footnote) STATEMENT OF POTENTIAL CONFLICT OF INTEREST C. Venter provided educational material or reviewed educational materials for Abbott Laboratories, Danone, and Reckitt Benckiser.L. O'Mahony has provided consultancy with Alimentary Health, research grant from GlaxoSmithKline. The other authors declare no conflicts of interest. (footnote) FUNDING/SUPPORT This work was supported by the National Institutes of Health, Grant Nos.: R01 DK076648/DK/NIDDK NIH HHS/United States, R01 GM121081/GM/NIGMS NIH HHS/United States, UG3 OD023248/OD/NIH HHS/United States, UH3 OD023248/OD/NIH HHS/United States, R25GM111901-S1, R25GM111901, and R00ES025817. (footnote) AUTHOR CONTRIBUTIONS C. Venter drafted the paper. M. P. Palumbo performed the data analysis and drafted the methods and results section, with D. H. Glueck and B. M. Ringham. B. F. Moore calculated the DII scores. K. A. Sauder and D. Dabelea (Principal Investigator of the Healthy Start study) provided data from the Healthy Start study and guided the project. L. O'Mahony and I. V. Yang assisted with the interpretation of asthma and immunology data. A. Starling assisted with interpretation of statistical analysis. All authors read the paper and contributed to interpretation of the data. Byline: Carina Venter, PhD, RD [Carina.Venter@childrenscolorado.org] (1,*), Michaela P. Palumbo, MS (2), Katherine A. Sauder, PhD (3,4), Deborah H. Glueck, PhD (5,6), Anne P. Starling, PhD (7,8), Brandy M. Ringham, PhD (6), Liam O'Mahony, PhD (9), Brianna F. Moore, PhD (6), Ivana V. Yang, PhD (10), Dana Dabelea, MD, PhD (11)

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Gale Document Number: GALE|A676152125