1 Lympogranuloma venereum (LGV) is an aggressive, sexually transmitted infection caused by specific strains of Chlamydia trachomatis
The L1, L2, and L3 strains are more invasive than those causing most anogenital infections. (1-4) Before 2004, LGV was rare in Canada, but has since become endemic. Between 2013 and 2020, 2052 C. trachomatis isolates forwarded to the National Microbiology Laboratory tested positive for LGV-causing strains (Dr. Alberto Severini, National Microbiology Laboratory, Winnipeg: personal communication, 2021). Outbreaks continue in Western Europe and North America, and primarily affect men who have sex with men. (2-6)
2 Lympogranuloma venereum can have variable presentations that can be misdiagnosed
Though LGV can be asymptomatic, the most common presentation is proctitis syndrome, whereby direct anal inoculation results in painful hemorrhagic proctitis, often mimicking inflammatory bowel disease. (1-6) In inguinal syndrome, however, infection usually begins with a painless papule, and subsequently progresses to ulceration and inguinal lymphadenopathy. (1,4) Systemic symptoms, such as fever, malaise and arthralgia, are often present. (2-6)
3 People with symptoms...