AGR3 Regulates Airway Epithelial Junctions in Patients with Frequent Exacerbations of COPD.

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Date: June 11, 2021
Publisher: Frontiers Research Foundation
Document Type: Article
Length: 405 words
Lexile Measure: 1330L

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Author(s): Rui Ye, Cuihong Wang, Pengbo Sun, Shuang Bai, Li Zhao

<bold>Background:</bold> The mechanisms underlying differences in the susceptibility to chronic obstructive pulmonary disease (COPD) exacerbations between patients are not well understood. Recent studies have shown that the patients with frequent COPD exacerbations is related to specific protein expression in lung tissue. Anterior gradient 3 (AGR3) is expressed in airway epithelial cells in the lung and proteomic analysis revealed that its expression is decreased in patients with frequent COPD exacerbations. Moreover, the loss of epithelial integrity might facilitate trans-epithelial permeability of pathogens in such patients. This study was performed to determine...

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Gale Document Number: GALE|A664884255