A selective activity-dependent requirement for dynamin 1 in synaptic vesicle endocytosis

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From: Science(Vol. 316, Issue 5824)
Publisher: American Association for the Advancement of Science
Document Type: Article
Length: 98 words
Lexile Measure: 1530L

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Abstract :

Dynamin 1 is a neuron-specific guanosine triphosphatase thought to be critically required for the fission reaction of synaptic vesicle endocytosis. Unexpectedly, mice lacking dynamin 1 were able to form functional synapses, even though their postnatat viability was limited. However, during spontaneous network activity, branched, tubular plasma membrane invaginations accumutated, capped by clathrin-coated pits, in synapses of dynamin 1-knockout mice. Synaptic vesicle endocytosis was severely impaired during strong exogenous stimulation but resumed efficiently when the stimulus was terminated. Thus, dynamin 1-independent mechanisms can support limited synaptic vesicle endocytosis, but dynamin 1 is needed during high levels of neuronal activity.

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Gale Document Number: GALE|A163680663