Fighting cancers from within: augmenting tumor immunity with cytokine therapy

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Date: Aug. 2010
From: Trends in Pharmacological Sciences(Vol. 31, Issue 8)
Publisher: Elsevier Science Publishers
Document Type: Report
Length: 185 words

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Abstract :

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.tips.2010.05.003 Byline: Marc Pellegrini (1), Tak W. Mak (2), Pamela S. Ohashi (2) Abstract: The human immune system has successfully evolved to fight many pathogens. Through vaccination, we can harness and improve immune responses to eradicate infections. Despite this success, we are only now beginning to understand the natural tumor immune surveillance mechanisms and why, in some instances, our immune system fails to abrogate the development and growth of tumors. Encouraging results with the latest immunotherapies have renewed enthusiasm in the field. A central component of these therapies is the contribution of cytokines. Here we review our expanding knowledge of cytokine-induced effects as well as preclinical and clinical data that indicate adjuvant cytokine therapies may hold much promise in improving anti-tumor immunity. Further studies on optimal synergistic combinations, timing, duration and additional adjuvant therapies are required to realize the full potential of cytokines as immunotherapeutic agents. Author Affiliation: (1) Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia (2) Campbell Family Institute for Breast Cancer Research, Toronto, Ontario M5G 2C1, Canada

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Gale Document Number: GALE|A233511038