Lipid heterogeneity resulting from fatty acid processing in the human breast cancer microenvironment identified by GCIB-ToF-SIMS imaging

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From: Analytical Chemistry(Vol. 88, Issue 23)
Publisher: American Chemical Society
Document Type: Report
Length: 83 words

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Abstract :

The gas cluster ion beams (GCIBs), time-of-flight secondary ion mass spectrometry (ToF-SIMS) is used to elucidate changes in lipid composition in nine breast cancer biopsy samples. Improved molecular signal generation by the GCIB produces location-specific information which reveals elevated levels of essential lipids to be related to inflammatory cells in the stroma, These changes in lipid composition due to different enzyme activity are seemingly independent of oxygen availability and can be linked to favorable cell membrane properties for either proliferation/invasion or drug resistance/survival.

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Gale Document Number: GALE|A476833131