Interaction of alpha-Thymidylate Kinase from Plasmodium Falciparum

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From: Biochemistry(Vol. 57, Issue 19)
Publisher: American Chemical Society
Document Type: Report
Length: 54 words

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Abstract :

This study , using Plasmodium falciparum thymidylate kinase (PfTMK) compound as a scaffold, developed number of Derivatives and, along with the original compound, characterized in terms of their enzyme inhibition (Ki) and binding affinity (KD). The study further observed significantly lower binding affinity and weaker inhibition of PfTMK than expected from the reported EC50.

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Gale Document Number: GALE|A542096467