Byline: Aoyjai P. Montgomery, School of Nursing (Drs Montgomery, Patrician, Miltner, and Polancich), Department of Health Services Administration (Dr Hall), and School of Public Health (Ms Enogela), University of Alabama at Birmingham; and University of Alabama at Birmingham Hospital (Dr Polancich).; Patricia A. Patrician; Allyson Hall; Rebecca S. Miltner; Ene M. Enogela; Shea Polancich Abstract BACKGROUND: COVID-19 negatively impacts many organ systems including the skin. One of the most significant skin-associated adverse events related to hospitalization are pressure injuries. PURPOSE: The aim of this study was to determine 8 risk factors that would place hospitalized patients at a higher risk for hospital-acquired pressure injuries (HAPIs) during the COVID-19 pandemic. METHODS: A retrospective, descriptive analysis was conducted in an urban academic health science center located in the southeastern United States. RESULTS: There were 247 of 23 093 patients who had pressure injuries and 1053 patients who had a positive COVID-19 diagnosis. Based on the generalized estimating equation model, diagnosis of COVID-19, age, male gender, risk of mortality, severity of illness, and length of stay are statistically significant factors associated with the development of HAPIs. CONCLUSIONS: Further study should explore pathology of COVID-19 skin changes and what interventions are effective against HAPIs in the COVID-19 population taking into consideration current treatments.