Effect of a Digital Intervention on Depressive Symptoms in Patients With Comorbid Hypertension or Diabetes in Brazil and Peru: Two Randomized Clinical Trials.

A digital intervention for patients with depressive symptoms and comorbid hypertension or diabetes might improve symptoms at 3 months compared with enhanced usual care. In 880 participants in Brazil and 432 participants in Peru, the proportion of participants who received the intervention experienced at least a 50% reduction in depressive symptoms at 3 months. The differences were no longer statistically relevant at 6 months.