Outcomes of extremely preterm infants following severe intracranial hemorrhage

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From: Journal of Perinatology(Vol. 34, Issue 3)
Publisher: Nature Publishing Group
Document Type: Clinical report
Length: 4,614 words
Lexile Measure: 1570L

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Abstract :

OBJECTIVE: Severe intracranial hemorrhage (ICH) is an important prognostic variable in extremely preterm (EPT) infants. We examined imaging and clinical variables that predict outcomes in EPT infants with severe ICH. STUDY DESIGN: Retrospective analysis of 353 EPT infants with severe ICH. Outcomes were compared by examining: (i) unilateral vs bilateral ICH; and (ii) presence vs absence of hemorrhagic parenchymal infarction (HPI). Regression analyses identified variables associated with death or neurodevelopmental impairment (NDI). RESULT: Bilateral ICH and HPI had higher rates of adverse outcomes and were independently associated with death/NDI. HPI was the most important variable for infants of lower birth weight, and bilateral ICH for larger infants. For infants surviving to 36 weeks, shunt placement was most associated with death/NDI. CONCLUSION: Bilateral ICH and the presence of HPI in EPT infants with severe ICH are associated with death/NDI, though the importance depends on birth weight and survival to 36 weeks. Journal of Perinatology (2014) 34, 203-208; doi:10.1038/jp.2013.162; published online 26 December 2013 Keywords: intraventricular hemorrhage; neurodevelopmental impairment; extremely low birth weight; cranial ultrasound

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Gale Document Number: GALE|A362850304