Intake of Lycopene and other Carotenoids and Incidence of Uterine Leiomyomata: A Prospective Ultrasound Study.

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Publisher: Elsevier Science Publishers
Document Type: Clinical report
Length: 655 words

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Keywords Leiomyoma; Diet; African Americans; Prospective studies; Ultrasonography Abstract Background Uterine leiomyomata (UL) are the leading indication for hysterectomy in the United States. Dietary supplementation with lycopene was associated with reduced size and incidence of oviduct leiomyoma in the Japanese quail. Two US prospective cohort studies of women reported little association between intake of lycopene, or other carotenoids, and UL incidence. However, these studies relied on self-reported physician-diagnosed UL, which is prone to misclassification. Objective This study examines the association between dietary intake of carotenoids and UL incidence. Design Data were derived from the Study of the Environment, Lifestyle, and Fibroids, a prospective cohort study. Women completed self-administered baseline questionnaires on demographic characteristics, reproductive history, and lifestyle, including a 110-item validated food frequency questionnaire, from which dietary intakes of carotenoids--including alpha carotene, beta carotene, cryptoxanthin, lutein-zeaxanthin, and lycopene--and vitamin A were estimated. Participants/setting One thousand two hundred thirty Black women aged 23 to 35 years who did not have a previous diagnosis of UL, cancer, or autoimmune disease were eligible for enrollment (2010-2012). Participants were residents of the Detroit, MI, metropolitan area. Main outcome measures Transvaginal ultrasound was used to assess UL at baseline and 20, 40, and 60 months of follow-up. Statistical analyses performed Cox regression was used to estimate hazard ratios and 95% CIs, adjusted for energy intake, age at menarche, education, body mass index, parity, age at first birth, years since last birth, current use of oral contraceptives or progestin-only injectables, alcohol intake, and cigarette smoking. Results Among 1,230 women without prevalent UL at baseline, 301 incident UL cases during follow-up were identified. Intakes of lycopene, other carotenoids, and vitamin A were not appreciably associated with UL incidence. Hazard ratios comparing quartiles 2 (2,376 to 3,397 [mu]g/day), 3 (3,398 to 4,817 [mu]g/day), and 4 ([greater than or equal to]4,818 [mu]g/day) with quartile 1 ( Conclusions Study findings do not support the hypothesis that greater carotenoid intake is associated with reduced UL incidence. Author Affiliation: 1Department of Epidemiology, Boston University School of Public Health, Boston, MA 2Department of Oncology, Georgetown Lombardi Comprehensive Cancer Center, Washington, DC 3Division of Medical Oncology, The Ohio State University College of Medicine; Columbus, OH 4Department of Public Health Sciences, Henry Ford Health System; Detroit, MI 5Epidemiology Branch, Women's Health Group, National Institute for Environmental Health Sciences, Research Triangle, NC 6NutritionQuest, Berkeley, CA * Address correspondence to: Lauren A. Wise, ScD, Department of Epidemiology, Boston University School of Public Health, Boston, MA 02118. Article History: Received 5 May 2020; Accepted 12 August 2020 (footnote) STATEMENT OF POTENTIAL CONFLICT OF INTEREST L. Wise serves as a fibroid consultant for AbbVie, Inc, on work that is unrelated to this article. No other potential conflict of interest was reported by the authors. (footnote) FUNDING/SUPPORT This work was supported by National Institutes of Health grants R01ES024749 and R01ES028235, the National Institute of Environmental Health Sciences Intramural Research Program, and the American Recovery and Reinvestment Act. (footnote) AUTHOR CONTRIBUTIONS D. D. Baird designed the parent study and D. D. Baird and G. Wegienka directed its overall implementation, including quality assurance and control. Dr. Wise directed the research project based on carotenoid intake and uterine leiomyomata. Q. Harmon and T. Block managed the datasets and A. K. Wesselink performed the statistical analyses. L. Wise conducted the literature review and took the lead in drafting the manuscript for final publication. All authors made contributions to interpretation of the results, drafting the manuscript, and revising the manuscript critically for intellectual content. L. Wise takes primary responsibility for the final content of the manuscript Byline: Lauren A. Wise, ScD [lwise@bu.edu] (1,*), Amelia K. Wesselink, PhD (1), Traci N. Bethea, PhD (2), Theodore M. Brasky, PhD (3), Ganesa Wegienka, PhD (4), Quaker Harmon, MD, PhD (5), Torin Block (6), Donna D. Baird, PhD (5)

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Gale Document Number: GALE|A648869799