Topical tretinoin therapy and all-cause mortality
Weinstock MA, Bingham SF, Lew RA et. al.
Arch Dermatol, 2009, 145, 18-24.
Retinoids have multiple effects on the skin  and are used both orally and topically in clinical practice to treat acne and psoriasis. Topical retinoic acid is also sold as Renova[R] for the treatment of photodamage. Retinoid compounds have also shown promise in treating preneoplastic and cancerous lesions. From the outset, this study was designed to investigate the potential use of high dose topical retinoic acid (0.1%) as a skin chemopreventative for the elderly. The study population included 1131 subjects (average age 71 years) randomised to tretinoin vs placebo control, with 97% of the subjects being male. These authors...