Cancer--Stromal Interactions in Scirrhous Gastric Carcinoma

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Date: Dec. 2010
From: Cancer Microenvironment(Vol. 3, Issue 1)
Publisher: Springer
Document Type: Report
Length: 155 words

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Abstract :

Byline: Masakazu Yashiro (1,2), Kosei Hirakawa (1) Keywords: Scirrhous gastric cancer; Fibroblasts; Stromal cells; Interaction; Microenvironment; Growth factor Abstract: Fibroblasts play an important role in the progression, growth and spread of gastric cancers. Cancer--stroma interactions have been especially evident in the scirrhous type of gastric carcinoma. Fibroblasts are associated with the cancer progression at the primary and metastatic site. The proliferative and invasive ability of scirrhous gastric cancer cells are closely associated with the growth factors produced by organ-specific fibroblasts. Fibroblasts are therefore a key determinant in the malignant progression of gastric cancer and represent an important target for cancer therapies. Author Affiliation: (1) Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan (2) Oncology Institute of Geriatrics and Medical Science, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka, Japan Article History: Registration Date: 04/01/2010 Received Date: 27/10/2009 Accepted Date: 03/01/2010 Online Date: 26/01/2010

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Gale Document Number: GALE|A280351721