Author(s): Jesús Avila [[dagger]] 2 , Carmen Laura Sayas 1
Evaluation of: Jin M, Shepardson N, Yang T, Chen G, Walsh D, Selkoe DJ. Soluble amyloid [beta]β-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration. Proc. Natl Acad. Sci. USA 108(14), 5819-5824 (2011).
Alzheimer'âs disease is characterized by the presence of two aberrant structures found in the brain of the patients: senile plaques (SPs) and neurofibrillary tangles. The main component of SPs is the [beta]β-amyloid peptide (A[beta]β) whereas the main component of neurofibrillary tangles is tau protein in its phosphorylated form. Genetic studies have suggested that in many cases of familial Alzheimer'âs disease, neurodegeneration is promoted by the appearance of A[beta]β that could play an initial role in the onset of the disease upon aggregation....