Combination of Huangqi Granule and Rosuvastatin Improves the Cardiac Function in Heart Failure.

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Date: May 2021
Publisher: New Century Health Publishers, LLC
Document Type: Article
Length: 4,146 words
Lexile Measure: 1430L

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Abstract :

Using rat models of heart failure, we evaluated the effects of rosuvastatin and Huangqi granule alone and in combination on left ventricular end-diastolic dimension, left ventricular end-systolic dimension, left ventricular ejection fraction, left ventricular posterior wall thickness at end-diastole, and left ventricular posterior wall thickness at end-systole. Results showed that left ventricular end-diastolic dimension, left ventricular end-systolic dimension in the rosuvastatin + Huangqi granule group were significantly decreased (P Keywords: Autophagy, Combination, Heart Failure, Huangqi granule, Resuvastatin, Therapeutic effect Abbreviations Used: 5'AMP-activated protein kinase, AMPK; S-methylglutathione, GSM; Heart failure, HF; Huangqi granule, HQ; Interferon-p, IFN-p; lnterleukin-2, IL-2; Microtubule-associated proteins 1A/1B light chain 3B, LC3; Left ventricular end-diastolic dimension, LVEDD; Left ventricular ejection fraction, LVEF; Left ventricular end-systolic dimension, LVESD; Left ventricular posterior wall thickness at end-diastole, LVPWTd; Left ventricular posterior wall thickness at end-systole, LVPWTs; Mammalian target of rapamycin, mTOR; Nitric oxide, NO; A cargo adaptor protein which interacts with autophagic substrates and delivers them to autophagosomes for degradation, p62; Phosphorylated 5' AMP-activated protein kinase, p-AMPK; Phosphorylated mammalian target of rapamycin, p-mTOR; Rosuvastatin, RVT; Superoxide dismutase, SOD; Tumor necrosis factor-[alpha], TNF-[alpha] Corresponding Author: Dr. Yuhong Ma, Department of General Practice, Affiliated Hospital of Inner Mongolia Medical University, No. 1, Tongdao North Road, Huimin District, Hohhot City, Inner Mongolia Autonomous Region, China; E-mail: yhma666@163.com

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Gale Document Number: GALE|A659273151