SIRT1 promotes differentiation of normal human keratinocytes
Blander G, Bhimavaparu A, Mammone T et al.
J Invest Dermatol, 2009, 129, 41-49
Sirtuins are associated with increasing lifespan (for a review see ). This is an interesting paper describing how sirtuins influence human epidermal keratinocyte differentiation and proliferation. Gene microarrays were used, which are known to provide cumbersome datasets requiring much dedicated data sorting. The authors addressed this problem by using computational systems biology to provide a causal network model generating hypotheses that were subsequently followed up by in vitro testing.
Sir2 is a gene family regulating ageing and lifespan in yeast, flies and worms. The human Sir2 gene family encodes for seven protein products, one of which, SIRT1, is a nicotinamide adenine dinucleoti-dedependent deacetylase controlling gene expression, cellular metabolism and cellular stress responses. SIRT1 has been shown to regulate cell differentiation in both muscle cells and adipocytes...