Identification of an Alternative Glycyrrhizin Metabolite Causing Liquorice-Induced Pseudohyperaldosteronism and the Development of ELISA System to Detect the Predictive Biomarker.

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Publisher: Frontiers Research Foundation
Document Type: Article
Length: 417 words
Lexile Measure: 1370L

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Author(s): Kan'ichiro Ishiuchi, Osamu Morinaga, Tetsuhiro Yoshino, Miaki Mitamura, Asuka Hirasawa, Yasuhito Maki, Yuuna Tashita, Tsubasa Kondo, Kakuyou Ogawa, Fangyi Lian, Keiko Ogawa-Ochiai, Kiyoshi Minamizawa, Takao Namiki, Masaru Mimura, Kenji Watanabe, Toshiaki Makino

Liquorice is usually used as crude drug in traditional Japanese Kampo medicine and traditional Chinese medicine. Liquorice-containing glycyrrhizin (GL) can cause pseudohyperaldosteronism as a side effect. Previously, we identified 18<italic>&beta;</italic>-glycyrrhetyl-3-<italic>O</italic>-sulfate (<bold>3</bold>) as a GL metabolite in Eisai hyperbilirubinuria rats (EHBRs) with the dysfunction of multidrug resistance-related protein (Mrp2). We speculated that <bold>3</bold> was associated with the onset of liquorice-induced pseudohyperaldosteronism, because it was mainly detected in serum of patients with suspected...

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Gale Document Number: GALE|A662032835