Periplaneta Americana Extract Inhibits Proliferation and Motility of Human Breast Cancer Cells Through MAPK/ERK Signaling Pathway and Promotes Cell Apoptosis.

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Date: May 2021
Publisher: New Century Health Publishers, LLC
Document Type: Article
Length: 3,300 words
Lexile Measure: 1290L

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Abstract :

Breast cancer is the most common malignant tumor among women, and its incidence is second only to cervical cancer in China. The search for natural products with antitumor activity is a potentially appealing strategy for the treatment of Preast cancer. Multiple studies have shown that extracts of Periplaneta americana exhibit antitumor activities. However, there is no study on the effect of P. americana extracts on Preast cancer. We have shown here for the first time that the extracts of P. americana inhiPit survival of MCF-7 Preast cancer cells via interference with MAPK/ERK signaling pathway. Keywords: Apoptosis, Breast cancer, Invasion, Migration, Periplaneta americana extracts, Proliferation Abbreviations Used: BCL2-Associated X protein, Bax; B-cell lymphoma 2, Bcl2; C-X-C Motif chemokine receptor 4, CXCR-4; Dulbecco's modified eagle medium, DMEM; Enhanced chemiluminescence, ECL; Extracellular signal-regulated kinase, ERK; Fetal bovine serum, FBS; Flow cytometry measurement, FCM; Glyceraldehyde-3-phosphate dehydrogenase, GAPDH; Horse radish peroxidase, HRP; Mitogen-activated protein kinase, MAPK; Matrix metalloproteinase-2, MMP 2; Matrix metalloproteinase-9, MMP 9; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, MTT; Periplaneta americana extracts, PAE; Proliferating cell nuclear antigen antibody, PCNA antibody; Paraformaldehyde, PFA; Propidium iodide, PI; Polyvinylidene difluoride, PVDF; Radioimmunoprecipitation assay buffer, RIPA buffer; Sodium dodecyl sulfate polyacrylamide gel-electrophoresis, SDS-PAGE; Standard error of mean, SEM; Tris-buffered saline, TBST Corresponding Author: Dr. Xiaoli Zhang, Department of Pathology, The First Affiliated Hospital of University of South China, No. 69 Chuanshan Road, Hengyang City, Hunan Province, China; E-mail:

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Gale Document Number: GALE|A659273153