Moisturizers change the mRNA expression of enzymes synthesizing skin barrier lipids

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Author: Helen Knaggs
Date: Sept. 2009
From: Clinical Dermatology(Vol. 25, Issue 3)
Publisher: Mediscript Ltd.
Document Type: Article
Length: 535 words
Lexile Measure: 1630L

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Moisturizers change the mRNA expression of enzymes synthesizing skin barrier lipids Buraczewska I, Berne B, Lindberg M, Loden M, Torma H.

Arch Dermatol Res, 2009, 301, 587-594

The last issue of this journal (25.2, June 2009) provided literature reviews of two papers [1,2] describing investigations on how retinoids influence gene expression. Retinoids play a major role in regulating growth, differentiation and apoptosis of many cell types, including keratinocytes, fibroblasts and sebocytes, and work through molecular mechanisms mediated through DNA sequences called retinoic acid response elements (RAREs) to regulate target genes [1]. Thus an effect of these compounds on gene expression would be expected. This paper, entitled 'Moisturizers change the mRNA expression of enzymes synthesizing skin barrier lipids', demonstrates that the change in barrier function brought about by using a moisturiser also involves changes...

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Gale Document Number: GALE|A213312721