Dexmedetomidine Mitigated NLRP3-Mediated Neuroinflammation via the Ubiquitin-Autophagy Pathway to Improve Perioperative Neurocognitive Disorder in Mice.

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Date: May 17, 2021
Publisher: Frontiers Research Foundation
Document Type: Article
Length: 471 words
Lexile Measure: 1350L

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Author(s): Lieliang Zhang, Fan Xiao, Jing Zhang, Xifeng Wang, Jun Ying, Gen Wei, Shoulin Chen, Xiangfei Huang, Wen Yu, Xing Liu, Qingcui Zheng, Guohai Xu, Shuchun Yu, Fuzhou Hua

<bold>Background:</bold> Surgery and anesthesia-induced perioperative neurocognitive disorder (PND) are closely related to NOD-like receptors (NLR) family, pyrin domain containing 3 (NLRP3) inflammasome microglia inflammatory response. Inhibiting the occurrence of neuroinflammation is an important treatment method to improve postoperative delirium. Fewer NLRP3-targeting molecules are currently available in the clinic to reduce the incidence of postoperative delirium. Dexmedetomidine (DEX), an [ALPHA]2 adrenergic receptor agonist has been shown to have antioxidant and anti-inflammatory activities. The present study showed that DEX reduced the production of cleaved caspase1 (CASP1) and destroyed the NLRP3-PYD...

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Gale Document Number: GALE|A662032828