Antimalarial Activity of Croton macrostachyus Stem Bark Extracts against Plasmodium berghei In Vivo

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From: Journal of Pathogens(Vol. 2018)
Publisher: Hindawi Limited
Document Type: Article
Length: 4,496 words
Lexile Measure: 1420L

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Abstract :

There is an increasing need for innovative drug and prophylaxis discovery against malaria. The aim of the present study was to test in vivo antiplasmodial activity of Croton macrostachyus H. (Euphorbiaceae) stem bark extracts from Kenyan folkloric medicine. Inbred Balb/c mice were inoculated with erythrocytes parasitized with Plasmodium berghei (ANKA). Different doses (500, 250, and 100 mg/kg) of C. macrostachyus ethyl acetate, methanol, aqueous, and isobutanol extracts were administrated either after inoculation (Peters' 4-day suppressive test) or before inoculation (chemoprotective test) of the parasitized erythrocytes. All the extracts showed significant suppression of parasitemia compared to control (p

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Gale Document Number: GALE|A584496926